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12 symptoms of excess hormones that you should know, one of which is enlarged legs and arms

Written By Hanny & Melissa on Wednesday, May 08, 2019 | Wednesday, May 08, 2019

https://www.economicfinancialpoliticalandhealth.com/2019/04/12-symptoms-of-excess-hormones-that-you.html
Hormones are chemical messengers between cells or between groups of cells. Hormones circulate in the blood circulation, and cell fluids to look for target cells.

When the hormone finds the target cell, the hormone binds to its receptor protein and sends a signal. The protein receptor will receive the signal, and react either by influencing the cell's genetic expression, or changing cellular protein activity.

And including, are stimulation or inhibition of growth and apoptosis, activation or deactivation of the immune system, regulation of metabolism and preparation of new activities, or phases of life. However, what happens if our body is overloaded with hormones ...?.

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Acromegaly is a disorder that arises because of the body's excess growth hormone, so that excessive growth occurs in various tissues of the body, muscles and bones, especially in the legs, hands, and face.

This condition is generally caused by a benign tumor in the pituitary gland. Increased growth hormone production can also be caused by tumors in other organs such as the lungs or pancreas, but very rarely.

Generally acromegaly is diagnosed in adult patients aged 40 to 45 years. This condition includes infrequent occurrence and minimal symptoms.

Most cases of sufferers know they have been attacked by acromegaly after years. Acromegaly can lead to life-threatening complications if not treated immediately.

Meanwhile, for the causes of acromegaly is the high production of Growth Hormone (GH) produced by the pituitary gland.

And 95% of acromegaly cases show tumors in the pituitary gland, which is the cause of increased GH production. In rare cases, offspring can be a trigger factor.

The pituitary gland is located in the lower part of the brain and functions to produce various important hormones for the body, one of which is Growth Hormone (GH).

Then, GH triggers the liver to produce Insulin-like Growth Factor I (IGF-I) as a stimulant for growth of bone and body tissue. Excessive GH levels will affect IGF-I production, triggering abnormal growth in body tissues, muscles, and bones.

For patients with pituitary tumors, acromegaly can be accompanied by other symptoms, namely if the tumor suppresses the nerves and tissues around the pituitary, or if the tumor also causes excessive production of thyroid hormone.

Next, not all acromegaly conditions show significant symptoms directly. Symptoms that appear will also be different from each sufferer. Some symptoms that can be experienced are:

1. Hands and feet enlarged.

2. The structure of the face changes.

3. The size of the tongue, nose, and lips enlarged.

4. Widened tooth structure.

5. Oily and rough skin.

6. Abnormal skin growth.

7. Excessive sweating, to body odor.

8. Dizziness, anxiety, muscle weakness.

9. Joint pain and mobility are limited.

10. Decreased vision function, deep and hoarse voice (widening of the vocal cords and sinuses).

11. Snoring loudly during sleep, the cavity enlarges (Barrel chest).

12. Impaired menstrual cycle in women, and erectile difficulties in men.

This condition can also cause important organs of the body such as the liver, kidneys, heart, and enlarged spleen that have the potential to endanger life. See a doctor immediately or visit the nearest hospital if you feel the symptoms above to get treatment earlier.

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Acromegaly & Treatment...

Treating acromegaly, focused on reducing the severity of symptoms, regulating excessive hormone levels, and restoring the function of the pituitary gland.

And the following are three methods of treatment, which are generally recommended in acromegaly cases. These 3 methods of treatment include:

1. Operation.

- Transfenoidal surgery is usually recommended to remove tumors from the pituitary that suppress nerves and trigger excessive GH production.

This action is carried out through the nose or upper lip, using endoscopy and other surgical instruments to remove the existing tumor.

This step of action is also carried out under local anesthesia. Suggestions for taking drugs and therapy, may be done before or after surgery.

2. Medicine.

The following medicines can be used for supporting treatment after surgery, or if surgery cannot be performed (For example in the case of large tumors) such as:

- Dopamine agonist.

Drugs such as bromocriptine and cabergoline serve to suppress growth hormone production. Both drugs are taken once or twice a week in pill form.

- Somatostatin analogue.

Drugs such as lanreotide and octreotide are used to control the production and flow of growth hormones, and reduce the size of adenoma tumors.

This drug is given in the form of an injection in the hospital, with an initial dose 3 times a day to see its effectiveness, and is continued once a month for a specified period. This injection is generally given under the skin (Subcutaneous) and in the buttock muscle (Gluteus muscle).

- Growth hormone antagonists.

One example of this drug is pegvisomant. This drug serves to block the effects of growth hormone on body tissues, suppress symptoms, and regulate IGF-I levels in the liver.

Growth hormone antagonists are usually given if the patient does not respond to other treatments, through subcutaneous injections once a day at the hospital. This drug cannot reduce tumor size or reduce hormone levels in the body.

- Radiotherapy.

Radiotherapy is generally recommended if the patient does not respond well to surgery or medication.

This therapy serves to destroy tumor cells that cannot be reached before and reduce growth hormone levels slowly. Radiotherapy can be done in 3 ways as below :

1. Conventional radiation therapy.

- Tumors are targeted to use an external beam that is given in small doses for a gap of 4 to 6 weeks. This is done to avoid damage to the pituitary gland and brain tissue, and provide time to heal radiation-affected tissue. The results of this therapy are generally felt after years.

2. Gamma knife therapy.

- Targeting the tumor directly using a strong radiation beam, without affecting the surrounding brain tissue. Patients will be asked to use a special head covering to minimize head movement.

This therapy is only done once, with results that can be felt after 3 to 5 years. Gamma knife therapy also risks causing smaller side effects than conventional radiation therapy.

3. Proton radiation therapy.

- Not much different from gamma knife therapy, proton radiation therapy emits strong radiation to the tumor with minimal effect on brain tissue. This therapy is given regularly, with a shorter intensity than conventional radiation therapy, happy friends...

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